swiss medicaXXI century S.A.Coming downstairs for breakfast had often been distressing for a four-year-old girl with autism spectrum disorder. Approximately two weeks after returning home from Swiss Medica, her mother described a different morning routine: her daughter came downstairs happily and ran into the kitchen ready to eat.
The family also reported longer sleep and fewer difficulties with emotional regulation. These were early observations made while the prescribed five-week home program was still ongoing.
Clinical Case · Patient overview
Before Treatment: The Girl’s Abilities and Main Challenges
The girl was diagnosed with ASD at approximately two and a half years old. Before her visit to Swiss Medica, her main support needs involved communication, sensory processing, emotional regulation, and sleep.
Her family’s account and a pre-treatment speech and language assessment described the following:
- Communication. She was non-speaking and mainly expressed her needs through hand-leading and pointing. She had begun exploring picture-based AAC and was starting to point to symbols to request preferred words, sounds, or activities. This remained an emerging skill, with a therapy goal of developing reliable single-word AAC communication across different activities.
- Attention and social interaction. Her attention was brief, particularly in busy or stimulating environments. She often moved away when other children approached, although she could share attention with another person for short periods. Quiet surroundings helped her focus.
- Sensory needs and emotional regulation. She had significant sensory-processing difficulties and could become intensely distressed. Episodes sometimes included self-injurious behavior, such as head banging. Moving between activities or places was particularly challenging.
- Sleep and safety. Her sleep was highly fragmented, averaging approximately three to four hours per night. She also had very limited awareness of danger.
The family hoped the program would support her engagement, communication, and emotional regulation while making sleep and everyday routines easier.
Treatment at Swiss Medica
The girl attended a nine-day regenerative program.
Treatment Details
| Component | Administration described in the clinical record |
| SENSA Cells | Intravenous administration at approximately 3 million cells/kg |
| Allogeneic umbilical cord-derived MSCs | Intramuscular administration of 30 million cells |
| Allogeneic placenta-derived MSCs | Intravenous administration at approximately 3 million cells/kg, plus 30 million cells intramuscularly |
| MSC-derived exosomes | Intravenous and intranasal administration |
| Autologous M2 macrophages | Included in the program |
| M2 macrophage secretome | Included in the program |
Following discharge, treatment continued at home with a prescribed five-week course of M2 macrophage secretome and intranasal MSC-derived exosomes.
Early Follow-Up: What Did Her Mother Notice?
Greater Emotional Regulation
Approximately two weeks after returning home, her mother described her daughter as considerably more emotionally regulated. She reported that there had been no meltdowns during that period.
This was a noticeable difference from the distress the family had described before treatment, when episodes could become severe and sometimes involve self-injury.
Easier Transitions in Everyday Routines
The family particularly noticed a change in how the girl managed transitions.
Previously, coming downstairs in the morning could leave her sitting on the floor, very upset. After returning home, her mother reported that she came downstairs happily and ran into the kitchen for breakfast.
For the family, this familiar morning activity provided a concrete example of a routine becoming easier and less distressing.
Longer Sleep Without Medication
Her mother also reported a substantial change in sleep. Before treatment, the girl had averaged approximately three to four fragmented hours per night. During the early follow-up period, she was reportedly sleeping around eight to ten hours per night without sleep medication.
Sleep and emotional regulation had both been central concerns for the family, making these the most prominent changes in their early account.
Continuing the Home Program
At the time of follow-up, the five-week home program was still ongoing. Her mother reported that the girl tolerated the intranasal sprays well and that the prescribed home routine was manageable.
Overall Outcome
At approximately two weeks after returning home, the mother’s observations suggest early positive functional changes compared with the girl’s pre-treatment status, particularly in emotional regulation, tolerance of everyday transitions, and sleep.
The reported period without meltdowns, easier mornings, and longer sleep had made familiar routines less distressing for the family. These observations were made during a very early follow-up period, while the home program was ongoing.
Continued follow-up would help establish whether these changes persist and how her attention, social engagement and communication—including her emerging AAC skills—develop over time.