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23 October 2020

How Do Stem Cells Work for MS?
Stem Cell Treatment for Multiple Sclerosis: Research
What Is the Difference Between HSCT and MSCs Treatment for MS?
Clinical Results: What Improvements Do Patients Get?
Treatment Results of Swiss Medica Patients
MS Treatment with Stem Cells: the Procedure
Indications and Contraindications for Cell Therapy
Safety Issues & Side Effects
What the Treatment Includes
Cumulative Statistical Report – Multiple Sclerosis Cases
List of References

nervous system multiple sclerosisMultiple sclerosis is the most common myelin disorder that affects the brain, spinal cord and optic nerves. In MS, the body’s own immune system attacks myelin – the coating around nerve fibers. Because of this, nerves get damaged, creating scarring and plaques. This disrupts nerve impulse transmission and communication between cells and causes problems related to muscle movement, balance, speech, and vision.

Patients with MS have a hard time altering medications to suit all of their needs. Steroids or disease-modifying drugs are aimed to manage specific symptoms, but they are often not fully successful in doing so, and cannot cover all the problems. Another concern is the critical side effects of drugs which sometimes dissuade patients from therapy. Because of this, many people turn to alternative methods such as treatment based on stem cells.

How Do Stem Cells Work for MS?

Studies show that these types of cells have the power to repair and rebuild myelin within the nervous system (in the case of intrathecal administration) [1]. When multipotent mesenchymal stem cells (MMSCs) enter the body, they find a place of damage and work on repairing it, while they also create new, healthy cells. In multiple sclerosis patients, they recover myelin, which leads to reforming on the patient’s nervous system and to reducing of symptoms.

Stem Cell Treatment for Multiple Sclerosis: Research

Until recently, it was believed that damaged brain tissue could not be repaired and would result in permanent, irreversible symptoms. However, recent medical findings have proven that the re-growth of brain cells and improvements in neurological function are possible.

Cell therapy based on MMSCs leads to the replacement of damaged cells and the restoration of the brain function. A growing number of reports indicate that adult stem cells have the ability to stimulate the generation of new neurons, oligodendrocytes, and astrocytes.

A clinical trial showed that treatment protocol with the use of stem cell-based products was safe, showed promise in improving lives, and the treatment protocol was well tolerated by patients [2].

Regenerative medicine as a method of treatment of multiple sclerosis gives hope for partial recovery, with some improvement of symptoms observed in virtually every case [3].

What Is the Difference Between HSCT and MSCs Treatment for MS?

For the treatment of multiple sclerosis, especially some of its types, hematopoietic stem cell transplantation (HSCT) is sometimes used as a multi-stage therapy that seeks to breakdown the patient’s immune system and then restore it using hematopoietic stem cells isolated from the patient’s or donated bone marrow. Such therapy allows to reviver the patient’s immune system so that it stops attacking its own myelin.

Unlike treatment using hematopoietic stem cells in conjunction with chemotherapy, the use of only mesenchymal stem cells gives a more sparing effect. While HSCT may be more effective in some cases, it also carries a large number of side effects associated with serious health risks, including graft-versus-host disease (GVHD), cytomegalovirus disease (CMV), endotheliitis, and other undesirable consequences.

In contrast to the above, using only mesenchymal stem cells without including immunosuppressive therapy in the treatment protocol is the most sparing option for treating MS using cell products. In this case, the patient receives intravenous and local injections of cells without damaging the immune system. MSCs are not related to the risk of rejection, and do not provoke the development of side effects, while the same as HSCT, having sufficient effectiveness to improve the condition in MS for most patients.

Clinical Results: What Improvements Do Patients Get?

The clinical effects of cell-based treatment programs for multiple sclerosis:

• Stimulates the formation of new blood vessels in the central nervous system.
• Increases strength in the limbs and muscles.
• Improves balance, increases patient endurance & ability to walk distances.
• Numbness of the limbs disappears.
• The severity of spasticity is reduced (spasm and other issues in the muscles).
• Fights fatigue and increases the overall energy level in patients.
• Improves endothelial function and regeneration of organs and tissues.
• Generally improves the quality of a patient’s life.

Get a free online consultation to learn what results you can expect from stem cell treatment >>

Treatment Results of Swiss Medica Patients

Relapsing-remitting multiple sclerosis. “I feel like I’m 50 years old again. I’m 80% better from my admission. It has changed my life.”

Relapsing-remitting multiple sclerosis treatment. “I’ve got my life back. And now I am 100% better than I was this time last year. I can walk my son to school. I can do things that I couldn’t do. Now I’m swimming 22 lengths twice a week. I just feel brilliant and I’m so excited.”

Multiple sclerosis treatment. “People have asked me, they are quite surprised that I’m in the gym for five days a week. It was really good to go out salmon fishing with a good friend of mine. I was able to hold conversations. My eye had cleared up, strengths and walking improved.”

More multiple sclerosis video testimonials are available on our YouTube channel.

Despite its healing properties, stem cells are not a guaranteed cure. The effectiveness of the therapy depends on multiple factors: initial condition, duration of the illness, age of the patient, hereditary predisposition, lifestyle, etc. Also, applying only stem cells for some cases may be not enough. Cell therapy works more effectively when combined with other therapeutic methods that help activate the tissue repair process.

MS Treatment with Stem Cells: the Procedure

Most commonly used cell product at Swiss Medica is based on multipotent mesenchymal stromal cells (MMSCs). During the therapy, a patient receives tens of millions of these cells. The quantity of restored plain cells not only covers daily losses but also exceeds them by thousands of times, renewing almost 10–15 years worth. This causes symptoms of a disease to improve and often makes the whole body and all organs healthier and rejuvenated because of the new and active cells which have replaced the old and damaged ones.

Treatment of multiple sclerosis with own (autologous) stem cells includes four basic procedures. First is harvesting; Fat or bone marrow is extracted through a simple process. Second is separation; Stem cells are separated in a centrifuge. The third is activation; The patient’s cells are photoactivated. Fourth is treatment; Cells are delivered to the body via standard IV drip or another route of administration.

In the case of donated tissues, cell products are already prepared and can be introduced immediately with no need to perform the harvesting procedure or to wait for the preparation of the cells.

Indications and Contraindications for Cell Therapy

Due to its benefits therapy with stem cells can be promising in the absence or insufficiency of the effect of the main therapy, and also in the presence of side effects from the medical drugs.

Contraindications are:

• previous bad experience with cell products;
• any type of cancer or a precancerous condition;
• any life-threatening or terminal health conditions;
• infectious disease in the acute stage;
• stroke or transient ischemic attack in the last 3 months;
• deviations of some indicators in blood tests;
• pregnancy and lactation;
• mental disorders and addictions;
• contraindications to anesthesia and/or high risk of bleeding and/or pathological processes in the area of the proposed biopsy (does not exclude the possibility of using donor cell products),
and some others.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>

Safety Issues & Side Effects

The procedure of stem cell therapy is very quick and simple. It does not require general anesthesia. In most cases there are no any side effects. Sometimes there may be a short-term increase in temperature and as an individual reaction of the body, but not more than 2% of cases. And it passes independently and does not entail negative consequences for the patient’s health.

Stem cell therapy does not cause any allergic and immune reactions (due to the immunoprivilege status of multipotent MMSCs). Good tolerability of the therapy is also proven [2].

What the Treatment Includes

Preparation for treatment includes the collection of medical reports to make a personal treatment program. Besides the administration of stem cells, we use optional additional therapies such as:

• Xenon gas rehabilitation therapy (inhalation procedure).
• Brain therapy by the magnetic field.
• Ozone-laser injection therapy.
• Transcranial brain stimulation.
• Neurorehabilitation.

These therapies help to activate the regeneration process, restore mobility, and improve symptoms. This complex yet beneficial impact on the entire body.

We also provide doctor consultations (specialists in neurology, neurorehabilitation, psychology, nutrition).

Q&A Video About Stem Cells for Multiple Sclerosis

Here is a video of the Q&A session with Dr. Alexandra, a specialist in regenerative medicine, Swiss Medica doctor. We are talking about a therapeutic approach based on the administration of cell products to patients suffering from multiple sclerosis (MS). Watch the video to find out:

• How stem cells work in MS and how do they help to fight the symptoms?
• What is the success rate of the treatment and what does it depend on?
• What additional therapies are used to increase the effect of the treatment?
• How the procedure is performed & is it painful?
• What improvements are expected with stem cell therapy for MS?

Cumulative Statistical Report – Multiple Sclerosis Cases

The goal of this MS Cumulative report is to assess the success of stem cell treatment in multiple sclerosis patients at Swiss Medica treatment center. Click on the picture to see the full report.

– Published on October 23, 2020

by Swiss Medica team

List of References:

[1]. Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection. Xue-Cheng Qiu, Hui Jin, Rong-Yi Zhang, Ying Ding, Xiang Zeng, Bi-Qin Lai, Eng-Ang Ling, Jin-Lang Wu, and Yuan-Shan Zeng. Stem Cell Research & Therapy. 2015; 6(1): 105.

[2]. Mesenchymal stem cells and conditioned media in the treatment of multiple sclerosis patients: Clinical, ophthalmological and radiological assessments of safety and efficacy. Said Dahbour, Fatima Jamali, Dana Alhattab, Ali Al‐Radaideh, Osama Ababneh, Nosaiba Al‐Ryalat, Muawyeh Al‐Bdour, Bayan Hourani, Mohammed Msallam, Murad Rasheed, Ammar Huneiti, Yacoub Bahou, Emad Tarawneh, and Abdalla Awidi corresponding author. CNS Neurosci Ther. 2017 Nov; 23(11): 866–874.

[3]. Sustained remission in multiple sclerosis after hematopoietic stem cell transplantation. Tolf A., Fagius J., Carlson K., Akerfeldt T., Granberg T., Larsson E.M., Burman J. Acta Neurol Scand. 2019 Jul 12.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>

Patient's results of treatment
at Swiss Medica

Parkinson's disease
Lyme disease
Multiple Sclerosis
Diabetes type 2
Kidney Disease

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About Swiss Medica clinic

Our primary task is to make your own cells treat your own body. We use advanced technology to activate mesenchymal stem cells derived from adipose tissue, bone marrow, etc. Donated cells can also be used. Introduced to the patient’s body, these cells help to regenerate damaged tissue. Symptoms become less obvious and/or disappear.

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