What results can be expected from the treatment of MS at our clinic?
The effectiveness of the therapy will depend on factors such as:
- the type of MS
- the duration of illness
- the patient’s age
- the current status of the patient (EDSS)
- the presence of other comorbidities
The expected outcomes of stem cell treatment for MS include:
- Significant increase in mobility: patients who used wheelchairs may regain the ability to walk with support, while patients who used a walker may return to independent movement
- Improvement in physical and mental activity
- Improved muscle tone
- Reduction in fatigue
- Overall improvement in quality of life
Increased resistance to the disease:
- Activation of the patient’s own stem cell pool and increase in their regenerative capacity
- Neoangiogenesis (stimulation of the growth of new blood vessels)
- Inhibition of autoimmune aggression
- Improved neuromuscular conduction
- General anti-inflammatory and immunomodulatory effects
Get a free online consultation with a medical adviser
1. Will stem cell therapy be beneficial for your case?
2. What improvements can you expect, and when?
2. What is the success rate of the therapy?
3. What is included in the stem cell treatment plan?
5. How much does stem cell therapy for MS cost?
6. What is the typical duration of the treatment?
Watch these video reviews from our patients to find out more about how it works:
How do we approach the treatment of multiple sclerosis for the best results?
Here is why people like you choose and recommend us
At Swiss Medica, we apply a comprehensive approach to therapy. In addition to the introduction of stem cells, our treatment programs include a range of additional therapies. A patient may be prescribed up to eight different procedures per day for the duration of the treatment process, which takes between 7 and 14 days.
There are four key areas in the complex treatment of multiple sclerosis and rehabilitation:
- Stem cell therapy. The key therapeutic effect in treating MS is achieved through stem cell introduction. The treatment has a powerful immunomodulatory effect, which helps stop the progression of the disease or mitigate its course. It also creates a regenerative effect which is important for recovery.
- IMR therapy. The primary purpose of IMR therapy is to create and maintain the most favourable environment for transplantable stem cells. Additionally, it saturates the patient’s cells with trace elements and increases their sensitivity (cellular response) improving their own regenerative potential.
- Kinesiotherapy. This type of treatment is used to restore the patient’s mobility. It also enhances the regenerative effect of stem cell introduction, as it helps to create new neural pathways and repair damaged ones.
- Concomitant forms of therapy. Selected therapies are prescribed based on the patient’s individual case and symptoms, and may include:
- Plasmapheresis (plasma exchange, Stanford protocol) – removes antibodies from blood circulation;
- Spark/Shock Wave therapy – activates processes of recovery in almost all tissues of the body and stimulates the regenerative processes in them;
- Super inductive system (SIS) – relieves pain and spasticity, increases joint mobility, and relaxes or strengthens muscles.
Features of stem cell therapy for MS at Swiss Medica
In most cases, mesenchymal stem cells (MSCs) are used for the treatment of multiple sclerosis. Specific cell preparations can be isolated both from the patient’s own tissues or those of a donor. The number of cells required for the transplantation depends primarily on the type of administration, the cell product, the patient’s condition, and the treatment strategy.
Which cells are used and how: common tissues and administration routes
- Stem cells from fat (adipose tissue)
- Bone marrow-derived stem cells
- Placenta stem cells
- Stem cells from the umbilical cord
- Stem cells from gingiva
- SVF, stromal-vascular fraction
Routes of administration:
- Retrobulbar in case of vision problems
- Intramuscular to restore tone and mobility
For more information about cell therapy, including specifics such as:
1. How injected stem cells act?
2. How the graft overcomes the blood-brain barrier?
3. The safety issues of therapy
Please leave a request and our medical advisors will contact you for a free online or phone consultation
Interview with Dr. Alexandra
Here is a video of the Q&A session with Dr. Alexandra, a specialist in regenerative medicine, Swiss Medica doctor. We are talking about a therapeutic approach based on the administration of cell products to patients suffering from multiple sclerosis (MS). Watch the video to find out:
- How stem cells in multiple sclerosis work and how do they help to fight the symptoms?
- What is the success rate of the treatment and what does it depend on?
- What additional therapies are used to increase the effect of the treatment?
- How the procedure is performed & is it painful?
- What improvements are expected with stem cell therapy for MS?
Jozeph about process of Stem Cell Treatment at Swiss Medica
This is a video story about one of our patients. He came to the Moscow clinic of Swiss Medica for stem cell treatment to cope with such pathologies as type 2 diabetes, high blood pressure, kidney disease, high cholesterol.
Studies show that these types of cells have the power to repair and rebuild myelin within the nervous system (in the case of intrathecal administration). When multipotent mesenchymal stem cells (MMSCs) enter the body, they find a place of damage and work on repairing it, while they also create new, healthy cells. In multiple sclerosis patients, they recover myelin, which leads to reforming on the patient’s nervous system and to reducing of symptoms.
Until recently, it was believed that damaged brain tissue could not be repaired and would result in permanent, irreversible symptoms. However, recent medical findings have proven that the re-growth of brain cells and improvements in neurological function are possible. Cell therapy based on MMSCs leads to the replacement of damaged cells and the restoration of the brain function. A growing number of reports indicate that adult stem cells have the ability to stimulate the generation of new neurons, oligodendrocytes, and astrocytes. A clinical trial showed that treatment protocol with the use of stem cell-based products was safe, showed promise in improving lives, and the treatment protocol was well tolerated by patients. Regenerative medicine as a method of treatment of multiple sclerosis gives hope for partial recovery, with some improvement of symptoms observed in virtually every case.
For the treatment of multiple sclerosis, especially some of its types, hematopoietic stem cell transplantation (HSCT) is sometimes used as a multi-stage therapy that seeks to breakdown the patient’s immune system and then restore it using hematopoietic stem cells isolated from the patient’s or donated bone marrow. Such therapy allows to reviver the patient’s immune system so that it stops attacking its own myelin. Unlike treatment using hematopoietic stem cells in conjunction with chemotherapy, the use of only mesenchymal stem cells gives a more sparing effect. While HSCT may be more effective in some cases, it also carries a large number of side effects associated with serious health risks, including graft-versus-host disease (GVHD), cytomegalovirus disease (CMV), endotheliitis, and other undesirable consequences. In contrast to the above, using only mesenchymal stem cells without including immunosuppressive therapy in the treatment protocol is the most sparing option for treating MS using cell products. In this case, the patient receives intravenous and local injections of cells without damaging the immune system. MSCs are not related to the risk of rejection, and do not provoke the development of side effects, while the same as HSCT, having sufficient effectiveness to improve the condition in MS for most patients.
Most commonly used cell product at Swiss Medica is based on multipotent mesenchymal stromal cells (MMSCs). During the therapy, a patient receives tens of millions of these cells. The quantity of restored plain cells not only covers daily losses but also exceeds them by thousands of times, renewing almost 10–15 years worth. This causes symptoms of a disease to improve and often makes the whole body and all organs healthier and rejuvenated because of the new and active cells which have replaced the old and damaged ones. Treatment of multiple sclerosis with own (autologous) stem cells includes four basic procedures. First is harvesting; Fat or bone marrow is extracted through a simple process. Second is separation; Stem cells are separated in a centrifuge. The third is activation; The patient’s cells are photoactivated. Fourth is treatment; Cells are delivered to the body via standard IV drip or another route of administration. In the case of donated tissues, cell products are already prepared and can be introduced immediately with no need to perform the harvesting procedure or to wait for the preparation of the cells.
Due to its benefits, therapy with stem cells can be promising in the absence or insufficiency of the effect of the main therapy, and also in the presence of side effects from the medical drugs. Contraindications are: • previous bad experience with cell products; • any type of cancer or a precancerous condition; • any life-threatening or terminal health conditions; • infectious disease in the acute stage; • stroke or transient ischemic attack in the last 3 months; • deviations of some indicators in blood tests; • pregnancy and lactation; • mental disorders and addictions; • contraindications to anesthesia and/or high risk of bleeding and/or pathological processes in the area of the proposed biopsy (does not exclude the possibility of using donor cell products), and some others.
The procedure of mesenchymal stem cell therapy for multiple sclerosis is very quick and simple. It does not require general anesthesia. In most cases there are no any side effects. Sometimes there may be a short-term increase in temperature and as an individual reaction of the body, but not more than 2% of cases. And it passes independently and does not entail negative consequences for the patient’s health. Stem cell therapy does not cause any allergic and immune reactions (due to the immunoprivilege status of multipotent MMSCs). Good tolerability of the therapy is also proven.
What is the cost of multiple sclerosis treatment with stem cells at Swiss Medica and how long does it take?
The cost of the program depends on the required type and number of procedures, while the total duration of treatment will depend on the current condition of the patient, their age, how long they have had the condition, the presence of comorbidities, etc.
In general, treatment programs range from 3 to 12 days, and the cost of a treatment day varies from €1,000 to €3,000.
To find out the exact length and price of treatment, please contact our medical consultants and get a free comprehensive consultation.
Stages of stem cell treatment for multiple sclerosis
An initial consultation takes place.
Medical advisors collect the patient’s anamnesis (we will need your medical reports).
The case is evaluated by a board of three or more doctors. As a result:
- Copy if there are any contraindications or the therapy is likely to be ineffective for a particular case, the patient may be refused for the treatment;
- additional patient data may be requested: results of tests and diagnostic procedures, etc;
- preparation of a specific treatment program will begin;
A follow-up consultation in which the patient can discuss and agree on the details of their treatment with their doctor
Pre-treatment, if necessary, may include basic treatment recommendations or the implementation of necessary therapies.
The patient arrives at the clinic. For your comfort, airport pick-up with an interpreter, transfer, and accomodation of the patient and an accompanying person are included in the program as standard.
Inpatient treatment at the clinic, with all meals and facilities provided.
Post-treatment will include remote consultations with the clinic’s doctors to track the patient’s progress and comply with discharge recommendations.
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List of References
Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection. Xue-Cheng Qiu, Hui Jin, Rong-Yi Zhang, Ying Ding, Xiang Zeng, Bi-Qin Lai, Eng-Ang Ling, Jin-Lang Wu, and Yuan-Shan Zeng. Stem Cell Research & Therapy. 2015; 6(1): 105.
Mesenchymal stem cells and conditioned media in the treatment of multiple sclerosis patients: Clinical, ophthalmological and radiological assessments of safety and efficacy. Said Dahbour, Fatima Jamali, Dana Alhattab, Ali Al‐Radaideh, Osama Ababneh, Nosaiba Al‐Ryalat, Muawyeh Al‐Bdour, Bayan Hourani, Mohammed Msallam, Murad Rasheed, Ammar Huneiti, Yacoub Bahou, Emad Tarawneh, and Abdalla Awidi corresponding author. CNS Neurosci Ther. 2017 Nov; 23(11): 866–874.
Sustained remission in multiple sclerosis after hematopoietic stem cell transplantation. Tolf A., Fagius J., Carlson K., Akerfeldt T., Granberg T., Larsson E.M., Burman J. Acta Neurol Scand. 2019 Jul 12.
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