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31 July 2019

Stem Cell Research in Strokes
Swiss Medica Reviews. Patient’s Experience in Post-stroke Condition
Post-stroke Recovery with Stem Cell Therapy
Indications and Contraindications for Cell Therapy
Safety Issues & Side Effects
Advantages of Stem Cell Therapy at Swiss Medica Clinics
What the Treatment Includes
List of References


Stroke is a leading cause of adult health impairment, with 15% to 30% of stroke patients becoming permanently disabled and 20% requiring institutional care for at least 3 months after stroke onset [1].

Stroke is a pathological condition in which brain tissue cells die within minutes from lack of oxygen and nutrients. Its consequences for someone’s overall health depend on the size of the lesion. However, there is always at least one ailment to the human brain and normal bodily functions that result from a stroke.

The only approved treatments of acute ischemic stroke involve restoring blood flow to the affected region by using thrombolytics or mechanical devices that physically remove clots. However, the use of thrombolytics is limited due to a therapeutic window of several days or even just a couple hours (depending on the drug) after the onset of stroke symptoms. Because of this, only a small fraction of stroke patients receive the required therapy in full. Further therapy is associated with long-term rehabilitation and recovery of lost functions, in which more progress can be made, but is not guaranteed.

What you are probably searching for is something that will bring the body back to the way it worked prior to the stroke. However, conservative medicine has no considerable methods which could promote recovery other than physical, occupational, and speech therapy. In recent years, the hope for improvement after a stroke has been associated with regenerative medicine. In particular, with the use of cell-based products.

During the therapy, stem cells are delivered intravenously, after which they are circulating through the bloodstream until reaching damaged areas. They then stimulate nerve cell renewal and the restoration of the brain begins. This leads to the improvement of all the symptoms associated with the condition.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>>

Stem Cell Research in Strokes

Until recently, brain tissue damage was considered permanent. But nowadays the possibility of brain cell regrowth and improvements in neurological function has been scientifically proven [2].

Cell-based treatment stimulates the re-growth of nerve tissue due to the therapeutic properties of stem cells.

The procedure of stem cell treatment is safe and proven to activate cells around the suffering brain tissue to catalyze rapid healing and to improve brain function [3]. Stem cell treatment improves the bending and straightening of the joints, increasing the agility in fingers. Muscle strength and control of limbs are improved, as well.

A large number of scientific reports indicate that adult stem cells have the ability to stimulate the generation of new neurons, oligodendrocytes, and astrocytes and to promote therapeutic benefits for stroke patients.

In vivo studies have shown that introduced stem cells, in particular, derived from the umbilical cord, have properties to:

• migrate into ischemic regions of the brain;
• increase the expression of several chemokines in the ischemic brain area (these tiny protein molecules promote tissue recovery);
• stimulate neurogenesis (formation of new normally functioning neurons);
• stimulates the growth of new vessels in the ischemic tissue area;
• modulate the immune response to damaged tissue both peripherally and locally;
• weaken local tissue ischemia, which helps to improve clinical outcomes [4].

In addition, stem cells rejuvenate the entire body. This natural human repair system helps to make all organs healthier.

Swiss Medica Reviews. Patient’s Experience in Post-stroke Condition

Stroke treatment results after 4th stem cell treatment (patient from the UK):

Stroke treatment experience (in Italian):

More patient experiences are available on our YouTube channel.

Despite its healing properties, stem cells are not a guaranteed cure. The effectiveness of the therapy depends on multiple factors: initial condition, duration of the illness, age of the patient, hereditary predisposition, lifestyle, etc. Also, applying only stem cells for some cases may be not enough. Cell therapy works more effectively when combined with other therapeutic methods that help activate the tissue repair process.

Post-stroke Recovery with Stem Cell Therapy

Swiss Medica clinic has developed a set of treatment protocols to address the patient’s post-stroke personalized needs. There is no necessity to wait for weeks to get treatment. To start, we apply injections of products based on stem cells with a high percentage of cell viability (about 90%).

In the therapy, the patient’s own stem cells are harvested from abdominal fat or bone marrow, then activated and put back into the body. Donated cells from different sources (the placenta, umbilical cord, etc.) can also be used. Large numbers of introduced active stem cells migrate to the brain and implement growth. In the process of stem cell treatment, tens of millions of cells are placed into the patient’s body. This amount exceeds the person’s daily losses of healthy cells by thousands of times. Naturally, such active cell replenishment rejuvenates and renews organs, displacing old and damaged cells.

We do not use embryos, hormones or chemical therapies during the procedure, so the treatment is virtually side-effect free. The whole procedure is quick and doesn’t even require general anesthesia.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>>

Indications and Contraindications for Cell Therapy

Due to its benefits, therapy with stem cells can be promising in the absence or insufficiency of the effect of the main therapy, and also in the presence of side effects from the medical drugs.

Contraindications are:

• previous bad experience with cell products;
• any type of cancer or a precancerous condition;
• any life-threatening or terminal health conditions;
• infectious disease in the acute stage;
• stroke or transient ischemic attack in the last 3 months;
• deviations of some indicators in blood tests;
• pregnancy and lactation;
• mental disorders and addictions;
• contraindications to anesthesia and/or high risk of bleeding and/or pathological processes in the area of the proposed biopsy (does not exclude the possibility of using donor cell products),
and some others.

Safety Issues & Side Effects

The procedure of stem cell therapy is very quick and simple. It does not require general anesthesia. In most cases there are no any side effects. Sometimes there may be a short-term increase in temperature and as an individual reaction of the body, but not more than 2% of cases. And it passes independently and does not entail negative consequences for the patient’s health.

Stem cell therapy does not cause any allergic and immune reactions (due to the immunoprivilege status of multipotent MMSCs).

Advantages of Stem Cell Therapy at Swiss Medica Clinics:

1. Low probability of minor adverse reactions (such as temperature rise during and/or after administration).
2. Avoidance of any allergic and immune reactions (due to the immunologically privileged status of stem cells).
3. General anesthesia is not required.
4. We apply only adult stem cells sourced from the patient (autologous) or donated.
5. The procedure is very quick and simple.
6. Only a small quantity of extracted cells is required for the therapy (which are then cultivated to the necessary amount).
7. The period of time between receiving lipoaspirate and the injection of the activated stem cells is only a few hours.

Q&A Video About Stem Cells for Post-Stroke Condition

Watch the Q&A video about the therapeutic application of cell-based products for patients with post-stroke. Dr. Alexandra, a specialist in regenerative medicine, Swiss Medica doctor, answers the most frequently asked questions regarding the topic. You will learn:

• How do stem cells work in our bodies?
• What improvements can a post-stroke patient get with cell therapy?
• What factors determine the success of recovery when using cell-based treatment?
• Does it work for every patient?

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>>

What the Treatment Includes:

After collecting your medical reports, we make a personal treatment program. Such a program usually includes not only the administration of cell product but also additional therapies, such as:

• Xenon gas rehabilitation therapy (inhalation procedure);
• Mesodiencephalic modulation (MDM);
• Electrical myostimulation;
• SIS (super inductive system);
• Oxygen therapy;
• Virtual reality;
• Kinesiotherapy,

and others.

Additional therapies that we use enhance the action of injected cells and help to achieve more pronounced improvements in post-stroke conditions.

– Published on July 31, 2019 by

Eremin Ilya Igorevich,

Vice Director for Science and Research,
MD, PhD;

Senior Research Associate at the Laboratory for Cellular Biology and Developmental Pathology at the Institute of General Pathology and Pathophysiology;

Associate Professor of the Department of Regenerative Medicine and Biomedical Technology at A.I. Yevdokimov Moscow State University of Medicine and Dentistry;

Member of the Department of Plastic and Reconstructive Surgery, Cosmetology and Cellular Technologies (Pirogov Russian National Research Medical University);

Member of International Federation for Adipose Therapeutics and Science (IFATS);

Member of International Society of Plastic & Regenerative Surgeons (ISPRES);

Member of Cell Society;

Member of International Placenta Stem Cells Society (IPLASS);

Author and co-author of more than 120 scientific articles, and co-author of 6 patents of invention.

List of References:

[1]. Symptomatic and palliative care for stroke survivors. Claire J. Creutzfeldt, MD, corresponding author Robert G. Holloway, MD, MPH, and Melanie Walker, MD. J Gen Intern Med. 2012 Jul; 27(7): 853–860.

[2]. Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke. Wei L., Wei Z.Z., Jiang M.Q., Mohamad O., Yu S.P. Prog Neurobiol. 2017 Oct;157:49-78.

[3]. Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats. Gómez-de Frutos M.C., Laso-García F., Diekhorst L., Otero-Ortega L., Fuentes B., Jolkkonen J., Detante O., Moisan A., Martínez-Arroyo A., Díez-Tejedor E., Gutiérrez-Fernández M.; RESSTORE consortium. Stem Cell Research&Therapy. 2019 Jul 17;10(1):212.

[4]. Human umbilical cord blood cell grafts for brain ischemia. Park D.H., Borlongan C.V., Willing A.E., Eve D.J., Cruz L.E., Sanberg C.D., Chung Y.G., Sanberg P.R. Cell Transplant. 2009;18(9):985-98.

Patient's results of treatment
at Swiss Medica

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About Swiss Medica clinic

Our primary task is to make your own cells treat your own body. We use advanced technology to activate mesenchymal stem cells derived from adipose tissue, bone marrow, etc. Donated cells can also be used. Introduced to the patient’s body, these cells help to regenerate damaged tissue. Symptoms become less obvious and/or disappear.

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