Clinical Case Reports: Children with ASD

Before treatment, she had unclear speech, frequent frustration, and disrupted sleep. She received one course of placental and umbilical cord mesenchymal stromal cells (MSCs) with stem cell exosomes. Follow-up noted longer, more complex sentences, better understanding of instructions, and less frequent frustration.

Before treatment, he had no functional speech, wore diapers, and usually ate with his hands. He received one course of placental and umbilical cord MSCs with stem cell exosomes. Follow-up noted independent toilet use, use of cutlery, and better understanding of instructions.

This boy had substantial difficulties with concentration, schoolwork, hyperactivity, and emotional distress. He received one course of therapy with MSCs and their exosomes. During a parent interview three months later, his family reported better organization and attention, greater independence with schoolwork, and more patience, although sleep difficulties persisted.

Before the program, this boy had communication difficulties, selective eating, and episodes of anxiety and aggression. He received one course of therapy with placental and umbilical cord stem cells and stem cell exosomes. Follow-up noted clearer pronunciation of some words, more interaction, and greater participation in games with other children.

Before treatment, he had limited conversational communication, poor concentration, and night-time waking. He received one course of placental and umbilical cord MSCs with stem cell exosomes and macrophages. Follow-up noted sleep from approximately 10 pm to 7 am, better responsiveness, and longer attention.

Before treatment, she used short sentences but did not answer questions or initiate communication, and needed help with daily routines. She received one course of placental and umbilical cord MSCs. Follow-up noted better understanding of complex instructions and greater comfort during family outings.

Before treatment, he rarely used words meaningfully, often screamed to express needs, and needed help with dressing and toileting. He received one course of placental and umbilical cord MSCs with their exosomes. Follow-up noted meaningful words and two-word phrases, attention lasting 10–15 minutes, and independent toilet use.

Before treatment, he rarely started conversations, struggled to describe feelings, and showed little interest in learning. He received two courses of placental and umbilical cord MSCs. Follow-up noted more spontaneous conversations, longer sentences, better expression of feelings, and greater interest in books and educational toys.

Before treatment, he had delayed speech, difficulty shifting attention, and frequent tantrums involving aggression. He received one course of placental and umbilical cord MSCs. Follow-up noted more spontaneous conversations, better engagement in tasks, and less frequent and intense tantrums.

Before treatment, he used short sentences, rarely initiated communication, and needed help with dressing and toileting. He received one course of placental and umbilical cord MSCs with stem cell exosomes. Follow-up noted more frequent speech, four-word sentences, better puzzle-solving focus, and progress with dressing.

Before treatment, she experienced anxiety, tantrums, selective eating, and disrupted sleep. She received one course of MSCs with their exosomes. Follow-up noted longer classroom participation, concentration lasting around ten minutes, and more sharing of thoughts and feelings.

Before treatment, she had poor attention, anxiety, and tantrums, sometimes biting herself when upset. She received one course of placental and umbilical cord MSCs. Follow-up noted better responsiveness to her name, improved understanding of speech, and calmer reactions to frustration.

Before treatment, he did not speak, needed help with dressing, and showed little interest in others or group games. He received one course of placental and umbilical cord stem cells with stem cell exosomes. Follow-up noted the words “mom” and “dad,” better understanding of instructions, independent shoe use, and interest in group games.

Before treatment, he rarely initiated communication, struggled with changes, and slept around three hours nightly. He received two courses of placental and umbilical cord MSCs with their exosomes. Follow-up noted longer conversations, imaginative play, independent toilet use, and longer uninterrupted sleep.

Before treatment, he used few words and had difficulty with motivation and focus. He received two courses of placental and umbilical cord MSCs. Follow-up noted attention lasting 10–15 minutes, better cooperation in play, and improved movement coordination.

Before treatment, he struggled to concentrate, showed little interest in lessons, and preferred playing alone. He received three courses of placental and umbilical cord MSCs. Follow-up noted greater interest and understanding in mathematics, better recognition of others’ emotions, and modestly improved concentration.

Before treatment, she struggled to express herself and understand speech, was not toilet trained, and needed dressing assistance. She received one course of placental and umbilical cord MSCs. Follow-up noted simple words expressing basic needs, better understanding of familiar instructions, and independent toilet use.

Before treatment, he was nonverbal, needed toileting support, and had sleep difficulties and a history of epilepsy. He received one course involving umbilical cord blood and another with placental and umbilical cord MSCs. Follow-up noted better understanding of basic instructions, more imitation and active play, and steadier walking.