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06 Aug 2019

Stem Cells Treatment for Dementia: How It Works
Stem Cell Therapy for Dementia: Patient Results
Stem Cell Therapy in Swiss Medica Clinic: the Procedure
Indications and Contraindications for Cell Therapy
Safety Issues & Side Effects
The Advantages of Our Treatment System
What the Treatment Includes
List of References
Dementia is a category of diseases that affect the brain and person’s cognitive abilities such as thinking and remembering, which can create numerous difficulties in daily activities [1]. This is a long term condition, which often progressively gets worse as the time passes. About 50-70% of all dementia cases are sufferers of Alzheimer’s disease, but there are other forms of dementia including vascular dementia, lewy body dementia, etc.

Dementia has a tendency to be misunderstood by many people who believe it is a natural part of aging, whilst others think that a simple forgetfulness means dementia. None of these beliefs are accurate. Although dementia mainly targets older population, those above ages of 65 and up, it is not a normal process that happens to everyone who grows old.

Pic. 1. Comparison of a normal aged brain (left) and the brain of a person with Dementia’s (right).

There is no cure for dementia at the moment and aside from providing help to the patient in a form of care and some medications that can slightly improve problems, for most people symptoms deteriorate. However, modern medicine improves daily and new discoveries such as stem cell treatment brought new hope and light to those suffering from this condition.

Stem cell therapy – the key treatment mode used in our clinic – is based on the insertion of new adult stem cells into mutilated tissue. Many specialists are sure that this method has the potential to alleviate the suffering of patients with dementia.

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Stem Cells Treatment for Dementia: How It Works

Cell-based therapy aims to restore degenerated neuronal networks, and consequently cognitive function, through the introduction of stem cells. Various scientific research asserts that stem cells make a great contribution to rebuilding damaged nerve fibers. These stem cells may be used as a cellular delivery system, utilizing a paracrine “bystander” mechanism through either native or induced production of neuroprotective growth factors. Alternatively, therapeutic restoration may occur through differentiation and participation of the stem cells in repopulating damaged neuronal circuits. This is a finely balanced, complex, and multistep process, with great potential benefit for those suffering from dementia [3].

In the process of stem cell treatment, tens of millions of cells are placed into the patient’s body. This amount exceeds the person’s daily losses of healthy cells by thousands of times. Naturally, such active cell replenishment rejuvenates and renews organs, displacing old and damaged cells.

Stem Cell Therapy for Dementia: Patient Results

A clinical trial showed such therapeutic effects of stem cell transplantation in dementia treatment as:
• increasing acetylcholine levels to improve cognition and memory;
• modulation of neuroplasticity and neurogenesis due to secreting neurotrophic factors by stem cells;
• increasing neuronal survival and neuronal differentiation;
• improving neuropathological and behavioral recovery;
• activation of microglia (glial cells that are located throughout the brain and spinal cord, and act as the first and main form of active immune defense in the central nervous system) [4].

Together, these effects lead to reducing symptoms.

Patient’s family experience who underwent stem cell treatment for dementia at Swiss Medica:

“My mom is walking better, she is holding a conversation better with me and our family” (patient from the UK).

More information on a typical case of dementia:

Despite its healing properties, stem cells are not a guaranteed cure. The effectiveness of the therapy depends on multiple factors: initial condition, duration of the illness, age of the patient, hereditary predisposition, lifestyle, etc. Also, applying only stem cells for some cases may be not enough. Cell therapy works more effectively when combined with other therapeutic methods that help activates the tissue repair process.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>

Stem Cell Therapy in Swiss Medica Clinic: the Procedure

In our clinic, patients receive activated autologous or allogeneic (taken from donated tissues) mesenchymal stem cell therapy. The cells are taken from bone marrow and/or adipose (fat) tissue. During the therapy process, no general anesthesia is needed. Our specialists take small amounts of body tissue to access stem cells, located in either bone marrow or the abdominal area (when using fat tissue), which are both easily accessible. After this simple process is completed, stem cells are separated from the tissue and activated. Finally, they are returned to the patient’s body using an IV drip.

The procedure is completely safe, quick, simple and painless. Donated cells from placenta or umbilical cord are also applied if required.

Indications and Contraindications for Cell Therapy

Due to its benefits, therapy with stem cells can be promising in the absence or insufficiency of the effect of the main therapy, and also in the presence of side effects from the medical drugs.

Contraindications are:

• previous bad experience with cell products;
• any type of cancer or a precancerous condition;
• any life-threatening or terminal health conditions;
• infectious disease in the acute stage;
• stroke or transient ischemic attack in the last 3 months;
• deviations of some indicators in blood tests;
• pregnancy and lactation;
• mental disorders and addictions;
• contraindications to anesthesia and/or high risk of bleeding and/or pathological processes in the area of the proposed biopsy (does not exclude the possibility of using donor cell products),
and some others.

Safety Issues & Side Effects

The procedure of stem cell therapy is very quick and simple. It does not require general anesthesia. In most cases there are no any side effects. Sometimes there may be a short-term increase in temperature and as an individual reaction of the body, but not more than 2% of cases. And it passes independently and does not entail negative consequences for the patient’s health.

Stem cell therapy does not cause any allergic and immune reactions (due to the immunoprivilege status of multipotent MMSCs).

The Advantages of Our Treatment System:

1. Low probability of side effects (rarely side effects such as short-term fever or temporary weakness are observed).
2. Stem cells themselves do not induce allergic or immune reactions.
3. General anesthesia is not required.
4. We apply only adult stem cells that are safe for the patient (no embryonic or fetal cells).
5. The procedure is quick and simple.
6. We apply both autologous (patient’s own) and donated cells, depending on the personal illness and medical needs.
7. We provide round-the-clock observation of doctors for the period of treatment.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>

What the Treatment Includes:

After collecting your medical reports, we make a personal treatment program. Such a program usually includes not only the administration of cell product but also additional therapies, such as:

• Transcranial brain stimulation;
• SIS (Super Inductive System);
• Xenon gas rehabilitation therapy;
• Brain therapy by the magnetic field,

and others.

These therapies stimulate the activity of introduced stem cells and contribute to the reduction of symptoms of Dementia. In General, this treatment has a rejuvenating effect for the whole body.

– Published on August 6, 2019 by

Eremin Ilya Igorevich,

Vice Director for Science and Research,
MD, PhD;

Senior Research Associate at the Laboratory for Cellular Biology and Developmental Pathology at the Institute of General Pathology and Pathophysiology;

Associate Professor of the Department of Regenerative Medicine and Biomedical Technology at A.I. Yevdokimov Moscow State University of Medicine and Dentistry;

Member of the Department of Plastic and Reconstructive Surgery, Cosmetology and Cellular Technologies (Pirogov Russian National Research Medical University);

Member of International Federation for Adipose Therapeutics and Science (IFATS);

Member of International Society of Plastic & Regenerative Surgeons (ISPRES);

Member of Cell Society;

Member of International Placenta Stem Cells Society (IPLASS);

Author and co-author of more than 120 scientific articles, and co-author of 6 patents of invention.

List of References:

[1]. What should we know about dementia in the 21st Century? A Delphi consensus study. Michael J. Annear, Christine Toye, Frances McInerny, Claire Eccleston, Bruce Tranter, Kate-Ellen Elliott, and Andrew Robinson. BMC Geriatrics. 2015; 15: 5.

[2]. Advances in the prevention of Alzheimer’s disease and dementia. Alina Solomon,1,2 Francesca Mangialasche,3 Edo Richard,4 Sandrine Andrieu,5 David A. Bennett,6 Monique Breteler,7 Laura Fratiglioni,3 Babak Hooshmand,3 Ara S. Khachaturian,8 Lon S. Schneider,9 Ingmar Skoog,10 and Miia Kivipelto. Journal of Internal Medicine. 2014 Mar; 275(3): 229–250.

[3]. Alzheimer’s disease, dementia, and stem cell therapy. Thomas Duncan and Michael Valenzuela. Stem Cell Research&Therapy. 2017; 8: 111.

[4]. Stem Cell Treatment for Alzheimer’s Disease. Ming Li, Kequan Guo, and Susumu Ikehara. International Journal of Molecular Science. 2014 Oct; 15(10): 19226–19238.

Get a free online consultation of Medical Advisor to find out if stem cells would work for you >>

Patient's results of treatment
at Swiss Medica

Parkinson's disease
Lyme disease
Multiple Sclerosis
Diabetes type 2
Kidney Disease

And what results can you get from stem cell treatment?

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2. What the treatment involves.

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About Swiss Medica clinic

Our primary task is to make your own cells treat your own body. We use advanced technology to activate mesenchymal stem cells derived from adipose tissue, bone marrow, etc. Donated cells can also be used. Introduced to the patient’s body, these cells help to regenerate damaged tissue. Symptoms become less obvious and/or disappear.

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*Patient feedback, articles and testimonials provided on this site are for informational purposes only and should not be considered as a guaranteed result for every case of illness. The treatment result depends on the disease, patient’s condition, number of treatment procedures, etc.

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